Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses
Identifieur interne : 002743 ( Main/Exploration ); précédent : 002742; suivant : 002744Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses
Auteurs : M. Hamzawi ; R. Jennings ; C. W. PotterSource :
- Journal of Hygiene [ 0022-1724 ] ; 1981-12.
Abstract
Inactivated vaccines prepared from influenza virus strains obtained by the recombination of A/PR/8/34 (H1N1) or A/FM/1/47 (H1N1) viruses with A/Victoria/3/75 (H3N2) virus, were tested for their antigenicity in hamsters. The parental origin of the genes of each cloned recombinant virus was determined by polyacrylamide gel electrophoresis, and vaccines prepared from each strain by concentration, purification on sucrose density gradients and inactivation with formalin. All the recombinant strains used in these studies possessed surface haemagglutinin and neuraminidase antigens derived from the A/Victoria/75 parent strain. On inoculation into hamsters, at equivalent concentrations, these vaccines varied in their ability to induce haemagglutination-inhibiting (HI) antibodies in the serum. This variation was not dependent on concentration and was observed using neutralization and single radial haemolysis, as well as HI. The possible reasons for the findings are discussed.
Url:
- https://api.istex.fr/ark:/67375/6GQ-PWRVLNBN-0/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134137
DOI: 10.1017/S0022172400069709
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000650
- to stream Istex, to step Curation: 000650
- to stream Istex, to step Checkpoint: 001375
- to stream Main, to step Merge: 002888
- to stream Pmc, to step Corpus: 000347
- to stream Pmc, to step Curation: 000347
- to stream Pmc, to step Checkpoint: 000D74
- to stream Ncbi, to step Merge: 001240
- to stream Ncbi, to step Curation: 001240
- to stream Ncbi, to step Checkpoint: 001240
- to stream Main, to step Merge: 002851
- to stream Main, to step Curation: 002743
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses</title><author><name sortKey="Hamzawi, M" sort="Hamzawi, M" uniqKey="Hamzawi M" first="M." last="Hamzawi">M. Hamzawi</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:590FB7D51F339BAF60A048D649A3892209787659</idno><date when="1981" year="1981">1981</date><idno type="doi">10.1017/S0022172400069709</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-PWRVLNBN-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000650</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000650</idno><idno type="wicri:Area/Istex/Curation">000650</idno><idno type="wicri:Area/Istex/Checkpoint">001375</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001375</idno><idno type="wicri:doubleKey">0022-1724:1981:Hamzawi M:antigenicity:in:hamsters</idno><idno type="wicri:Area/Main/Merge">002888</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134137</idno><idno type="RBID">PMC:2134137</idno><idno type="wicri:Area/Pmc/Corpus">000347</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000347</idno><idno type="wicri:Area/Pmc/Curation">000347</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000347</idno><idno type="wicri:Area/Pmc/Checkpoint">000D74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D74</idno><idno type="wicri:Area/Ncbi/Merge">001240</idno><idno type="wicri:Area/Ncbi/Curation">001240</idno><idno type="wicri:Area/Ncbi/Checkpoint">001240</idno><idno type="wicri:doubleKey">0022-1724:1981:Hamzawi M:antigenicity:in:hamsters</idno><idno type="wicri:Area/Main/Merge">002851</idno><idno type="wicri:Area/Main/Curation">002743</idno><idno type="wicri:Area/Main/Exploration">002743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses</title><author><name sortKey="Hamzawi, M" sort="Hamzawi, M" uniqKey="Hamzawi M" first="M." last="Hamzawi">M. Hamzawi</name><affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1981-12">1981-12</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="453">453</biblScope><biblScope unit="page" to="464">464</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Inactivated vaccines prepared from influenza virus strains obtained by the recombination of A/PR/8/34 (H1N1) or A/FM/1/47 (H1N1) viruses with A/Victoria/3/75 (H3N2) virus, were tested for their antigenicity in hamsters. The parental origin of the genes of each cloned recombinant virus was determined by polyacrylamide gel electrophoresis, and vaccines prepared from each strain by concentration, purification on sucrose density gradients and inactivation with formalin. All the recombinant strains used in these studies possessed surface haemagglutinin and neuraminidase antigens derived from the A/Victoria/75 parent strain. On inoculation into hamsters, at equivalent concentrations, these vaccines varied in their ability to induce haemagglutination-inhibiting (HI) antibodies in the serum. This variation was not dependent on concentration and was observed using neutralization and single radial haemolysis, as well as HI. The possible reasons for the findings are discussed.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hamzawi, M" sort="Hamzawi, M" uniqKey="Hamzawi M" first="M." last="Hamzawi">M. Hamzawi</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002743 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002743 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:590FB7D51F339BAF60A048D649A3892209787659
|texte= Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses
}}
| This area was generated with Dilib version V0.6.33. |  |